Christoffer Norn

Affiliations

Department of Biochemistry, University of Washington, Seattle, WA, USA.
Institute for Protein Design, University of Washington, Seattle, WA, USA.
BioInnovation Institute, DK2200 Copenhagen N, Denmark.

Publications (14)

Top-down design of protein architectures with reinforcement learning.

Science (New York, N.Y.)

Avec: Isaac D Lutz , Shunzhi Wang , Christoffer Norn , Alexis Courbet , Andrew J Borst , Yan Ting Zhao , Annie Dosey , Longxing Cao , Jinwei Xu , Elizabeth M Leaf , Catherine Treichel , Patrisia Litvicov , Zhe Li , Alexander D Goodson , Paula Rivera-Sánchez , Ana-Maria Bratovianu , Minkyung Baek , Neil P King , Hannele Ruohola-Baker , David Baker

Macromolecular modeling and design in Rosetta: recent methods and frameworks.

Nature methods

Avec: Julia Koehler Leman , Brian D Weitzner , Steven M Lewis , Jared Adolf-Bryfogle , Nawsad Alam , Rebecca F Alford , Melanie Aprahamian , David Baker , Kyle A Barlow , Patrick Barth , Benjamin Basanta , Brian J Bender , Kristin Blacklock , Jaume Bonet , Scott E Boyken , Phil Bradley , Chris Bystroff , Patrick Conway , Seth Cooper , Bruno E Correia , Brian Coventry , Rhiju Das , René M De Jong , Frank DiMaio , Lorna Dsilva , Roland Dunbrack , Alexander S Ford , Brandon Frenz , Darwin Y Fu , Caleb Geniesse , Lukasz Goldschmidt , Ragul Gowthaman , Jeffrey J Gray , Dominik Gront , Sharon Guffy , Scott Horowitz , Po-Ssu Huang , Thomas Huber , Tim M Jacobs , Jeliazko R Jeliazkov , David K Johnson , Kalli Kappel , John Karanicolas , Hamed Khakzad , Karen R Khar , Sagar D Khare , Firas Khatib , Alisa Khramushin , Indigo C King , Robert Kleffner , Brian Koepnick , Tanja Kortemme , Georg Kuenze , Brian Kuhlman , Daisuke Kuroda , Jason W Labonte , Jason K Lai , Gideon Lapidoth , Andrew Leaver-Fay , Steffen Lindert , Thomas Linsky , Nir London , Joseph H Lubin , Sergey Lyskov , Jack Maguire , Lars Malmström , Enrique Marcos , Orly Marcu , Nicholas A Marze , Jens Meiler , Rocco Moretti , Vikram Khipple Mulligan , Santrupti Nerli , Christoffer Norn , Shane Ó'Conchúir , Noah Ollikainen , Sergey Ovchinnikov , Michael S Pacella , Xingjie Pan , Hahnbeom Park , Ryan E Pavlovicz , Manasi Pethe , Brian G Pierce , Kala Bharath Pilla , Barak Raveh , P Douglas Renfrew , Shourya S Roy Burman , Aliza Rubenstein , Marion F Sauer , Andreas Scheck , William Schief , Ora Schueler-Furman , Yuval Sedan , Alexander M Sevy , Nikolaos G Sgourakis , Lei Shi , Justin B Siegel , Daniel-Adriano Silva , Shannon Smith , Yifan Song , Amelie Stein , Maria Szegedy , Frank D Teets , Summer B Thyme , Ray Yu-Ruei Wang , Andrew Watkins , Lior Zimmerman , Richard Bonneau

Atomistic simulation of protein evolution reveals sequence covariation and time-dependent fluctuations of site-specific substitution rates.

PLoS computational biology

Avec: Christoffer Norn , Ingemar André

De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles.

bioRxiv : the preprint server for biology

Avec: Linna An , Meerit Said , Long Tran , Sagardip Majumder , Inna Goreshnik , Gyu Rie Lee , David Juergens , Justas Dauparas , Ivan Anishchenko , Brian Coventry , Asim K Bera , Alex Kang , Paul M Levine , Valentina Alvarez , Arvind Pillai , Christoffer Norn , David Feldman , Dmitri Zorine , Derrick R Hicks , Xinting Li , Mariana Garcia Sanchez , Dionne K Vafeados , Patrick J Salveson , Anastassia A Vorobieva , David Baker

De novo design of luciferases using deep learning.

Nature

Avec: Andy Hsien-Wei Yeh , Christoffer Norn , Yakov Kipnis , Doug Tischer , Samuel J Pellock , Declan Evans , Pengchen Ma , Gyu Rie Lee , Jason Z Zhang , Ivan Anishchenko , Brian Coventry , Longxing Cao , Justas Dauparas , Samer Halabiya , Michelle DeWitt , Lauren Carter , K N Houk , David Baker

Improved prediction of site-rates from structure with averaging across homologs.

Protein science : a publication of the Protein Society

Avec: Christoffer Norn , Fábio Oliveira , Ingemar André

Protein sequence design by conformational landscape optimization.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Christoffer Norn , Basile I M Wicky , David Juergens , Sirui Liu , David Kim , Doug Tischer , Brian Koepnick , Ivan Anishchenko , Auteur inconnu , David Baker , Sergey Ovchinnikov

Binding and sensing diverse small molecules using shape-complementary pseudocycles.

Science (New York, N.Y.)

Small-molecule binding and sensing with a designed protein family.

bioRxiv : the preprint server for biology

Avec: Gyu Rie Lee , Samuel J Pellock , Christoffer Norn , Doug Tischer , Justas Dauparas , Ivan Anischenko , Jaron A M Mercer , Alex Kang , Asim Bera , Hannah Nguyen , Inna Goreshnik , Dionne Vafeados , Nicole Roullier , Hannah L Han , Brian Coventry , Hugh K Haddox , David R Liu , Andy Hsien-Wei Yeh , David Baker

An enumerative algorithm for de novo design of proteins with diverse pocket structures.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Benjamin Basanta , Matthew J Bick , Asim K Bera , Christoffer Norn , Cameron M Chow , Lauren P Carter , Inna Goreshnik , Frank Dimaio , David Baker

A thermodynamic model of protein structure evolution explains empirical amino acid substitution matrices.

Protein science : a publication of the Protein Society

Avec: Christoffer Norn , Ingemar André , Douglas L Theobald

De novo protein design by deep network hallucination.

Nature

Avec: Ivan Anishchenko , Samuel J Pellock , Tamuka M Chidyausiku , Theresa A Ramelot , Sergey Ovchinnikov , Jingzhou Hao , Khushboo Bafna , Christoffer Norn , Alex Kang , Asim K Bera , Frank DiMaio , Lauren Carter , Cameron M Chow , Gaetano T Montelione , David Baker

Computational design of sequence-specific DNA-binding proteins.

bioRxiv : the preprint server for biology

Avec: Cameron J Glasscock , Robert Pecoraro , Ryan McHugh , Lindsey A Doyle , Wei Chen , Olivier Boivin , Beau Lonnquist , Emily Na , Yuliya Politanska , Hugh K Haddox , David Cox , Christoffer Norn , Brian Coventry , Inna Goreshnik , Dionne Vafeados , Gyu Rie Lee , Raluca Gordan , Barry L Stoddard , Frank DiMaio , David Baker

Computational design of serine hydrolases.

bioRxiv : the preprint server for biology

Avec: Anna Lauko , Samuel J Pellock , Ivan Anischanka , Kiera H Sumida , David Juergens , Woody Ahern , Alex Shida , Andrew Hunt , Indrek Kalvet , Christoffer Norn , Ian R Humphreys , Cooper Jamieson , Alex Kang , Evans Brackenbrough , Asim K Bera , Banumathi Sankaran , K N Houk , David Baker

Réseau de co-auteurs

David Baker 11 collaborations

Brian Coventry 6 collaborations

Inna Goreshnik 5 collaborations

Gyu Rie Lee 5 collaborations

Ivan Anishchenko 5 collaborations

Asim K Bera 5 collaborations

Alex Kang 5 collaborations

David Juergens 4 collaborations

Justas Dauparas 4 collaborations

Samuel J Pellock 4 collaborations

Frank DiMaio 3 collaborations

Sergey Ovchinnikov 3 collaborations

Ingemar André 3 collaborations

Doug Tischer 3 collaborations

Longxing Cao 2 collaborations

Benjamin Basanta 2 collaborations

Brian Koepnick 2 collaborations

Linna An 2 collaborations

Meerit Said 2 collaborations

Long Tran 2 collaborations

Sagardip Majumder 2 collaborations

Paul M Levine 2 collaborations

Valentina Alvarez 2 collaborations

Arvind Pillai 2 collaborations

David Feldman 2 collaborations

Dmitri Zorine 2 collaborations

Derrick R Hicks 2 collaborations

Xinting Li 2 collaborations

Mariana Garcia Sanchez 2 collaborations

Dionne K Vafeados 2 collaborations

Patrick J Salveson 2 collaborations

Anastassia A Vorobieva 2 collaborations

Andy Hsien-Wei Yeh 2 collaborations

Lauren Carter 2 collaborations

K N Houk 2 collaborations

Dionne Vafeados 2 collaborations

Hugh K Haddox 2 collaborations

Cameron M Chow 2 collaborations

Isaac D Lutz 1 collaboration

Shunzhi Wang 1 collaboration

Alexis Courbet 1 collaboration

Andrew J Borst 1 collaboration

Yan Ting Zhao 1 collaboration

Annie Dosey 1 collaboration

Jinwei Xu 1 collaboration

Elizabeth M Leaf 1 collaboration

Catherine Treichel 1 collaboration

Patrisia Litvicov 1 collaboration

Zhe Li 1 collaboration

Alexander D Goodson 1 collaboration

Paula Rivera-Sánchez 1 collaboration

Ana-Maria Bratovianu 1 collaboration

Minkyung Baek 1 collaboration

Neil P King 1 collaboration

Hannele Ruohola-Baker 1 collaboration

Julia Koehler Leman 1 collaboration

Brian D Weitzner 1 collaboration

Steven M Lewis 1 collaboration

Jared Adolf-Bryfogle 1 collaboration

Nawsad Alam 1 collaboration

Rebecca F Alford 1 collaboration

Melanie Aprahamian 1 collaboration

Kyle A Barlow 1 collaboration

Patrick Barth 1 collaboration

Brian J Bender 1 collaboration

Kristin Blacklock 1 collaboration

Jaume Bonet 1 collaboration

Scott E Boyken 1 collaboration

Phil Bradley 1 collaboration

Chris Bystroff 1 collaboration

Patrick Conway 1 collaboration

Seth Cooper 1 collaboration

Bruno E Correia 1 collaboration

Rhiju Das 1 collaboration

René M De Jong 1 collaboration

Lorna Dsilva 1 collaboration

Roland Dunbrack 1 collaboration

Alexander S Ford 1 collaboration

Brandon Frenz 1 collaboration

Darwin Y Fu 1 collaboration

Caleb Geniesse 1 collaboration

Lukasz Goldschmidt 1 collaboration

Ragul Gowthaman 1 collaboration

Jeffrey J Gray 1 collaboration

Dominik Gront 1 collaboration

Sharon Guffy 1 collaboration

Scott Horowitz 1 collaboration

Po-Ssu Huang 1 collaboration

Thomas Huber 1 collaboration

Tim M Jacobs 1 collaboration

Jeliazko R Jeliazkov 1 collaboration

David K Johnson 1 collaboration

Kalli Kappel 1 collaboration

John Karanicolas 1 collaboration

Hamed Khakzad 1 collaboration

Karen R Khar 1 collaboration

Sagar D Khare 1 collaboration

Firas Khatib 1 collaboration

Alisa Khramushin 1 collaboration

Indigo C King 1 collaboration

Robert Kleffner 1 collaboration

Tanja Kortemme 1 collaboration

Georg Kuenze 1 collaboration

Brian Kuhlman 1 collaboration

Daisuke Kuroda 1 collaboration

Jason W Labonte 1 collaboration

Jason K Lai 1 collaboration

Gideon Lapidoth 1 collaboration

Andrew Leaver-Fay 1 collaboration

Steffen Lindert 1 collaboration

Thomas Linsky 1 collaboration

Nir London 1 collaboration

Joseph H Lubin 1 collaboration

Sergey Lyskov 1 collaboration

Jack Maguire 1 collaboration

Lars Malmström 1 collaboration

Enrique Marcos 1 collaboration

Orly Marcu 1 collaboration

Nicholas A Marze 1 collaboration

Jens Meiler 1 collaboration

Rocco Moretti 1 collaboration

Vikram Khipple Mulligan 1 collaboration

Santrupti Nerli 1 collaboration

Shane Ó'Conchúir 1 collaboration

Noah Ollikainen 1 collaboration

Michael S Pacella 1 collaboration

Xingjie Pan 1 collaboration

Hahnbeom Park 1 collaboration

Ryan E Pavlovicz 1 collaboration

Manasi Pethe 1 collaboration

Brian G Pierce 1 collaboration

Kala Bharath Pilla 1 collaboration

Barak Raveh 1 collaboration

P Douglas Renfrew 1 collaboration

Shourya S Roy Burman 1 collaboration

Aliza Rubenstein 1 collaboration

Marion F Sauer 1 collaboration

Andreas Scheck 1 collaboration

William Schief 1 collaboration

Ora Schueler-Furman 1 collaboration

Yuval Sedan 1 collaboration

Alexander M Sevy 1 collaboration

Nikolaos G Sgourakis 1 collaboration

Lei Shi 1 collaboration

Justin B Siegel 1 collaboration

Daniel-Adriano Silva 1 collaboration

Shannon Smith 1 collaboration

Yifan Song 1 collaboration

Amelie Stein 1 collaboration

Maria Szegedy 1 collaboration

Frank D Teets 1 collaboration

Summer B Thyme 1 collaboration

Ray Yu-Ruei Wang 1 collaboration

Andrew Watkins 1 collaboration

Lior Zimmerman 1 collaboration

Richard Bonneau 1 collaboration

Yakov Kipnis 1 collaboration

Declan Evans 1 collaboration

Pengchen Ma 1 collaboration

Jason Z Zhang 1 collaboration

Samer Halabiya 1 collaboration

Michelle DeWitt 1 collaboration

Fábio Oliveira 1 collaboration

Basile I M Wicky 1 collaboration

Sirui Liu 1 collaboration

David Kim 1 collaboration

None None 1 collaboration

Ivan Anischenko 1 collaboration

Jaron A M Mercer 1 collaboration

Asim Bera 1 collaboration

Hannah Nguyen 1 collaboration

Nicole Roullier 1 collaboration

Hannah L Han 1 collaboration

David R Liu 1 collaboration

Matthew J Bick 1 collaboration

Lauren P Carter 1 collaboration

Frank Dimaio 1 collaboration

Douglas L Theobald 1 collaboration

Tamuka M Chidyausiku 1 collaboration

Theresa A Ramelot 1 collaboration

Jingzhou Hao 1 collaboration

Khushboo Bafna 1 collaboration

Gaetano T Montelione 1 collaboration

Cameron J Glasscock 1 collaboration

Robert Pecoraro 1 collaboration

Ryan McHugh 1 collaboration

Lindsey A Doyle 1 collaboration

Wei Chen 1 collaboration

Olivier Boivin 1 collaboration

Beau Lonnquist 1 collaboration

Emily Na 1 collaboration

Yuliya Politanska 1 collaboration

David Cox 1 collaboration

Raluca Gordan 1 collaboration

Barry L Stoddard 1 collaboration

Anna Lauko 1 collaboration

Ivan Anischanka 1 collaboration

Kiera H Sumida 1 collaboration

Woody Ahern 1 collaboration

Alex Shida 1 collaboration

Andrew Hunt 1 collaboration

Indrek Kalvet 1 collaboration

Ian R Humphreys 1 collaboration

Cooper Jamieson 1 collaboration

Evans Brackenbrough 1 collaboration

Banumathi Sankaran 1 collaboration